About coenzyme Q10
Coenzyme Q10 is fat soluble molecule, present in every cell of our bodies. It is crucial for energy metabolism and more than 95% of energy in our bodies is made by process regulated by CoQ10. It is also incredibly powerful antioxidant and serves an important role in fighting free radicals that can damage our cells. It is one of the most important micronutrients in our bodies and without it, we couldn’t exist.
How CoQ10 works?
Mitochondria is part of the cell responsible for transforming nutrients into energy. Energy formed in this “mini factories” is crucial for sustaining energy to perform body functions. The conversion process – food into energy – cannot be started without CoQ10.
CoQ10 has the ability to accept and donate electrons and this crucial feature helps it to cancel out dangerous free radicals. Additionally it helps recycle vitamins C and E, so it maximizes efficiency of this both powerful antioxidants in our bodies.
A key advantage of Q10 lies in its presence in the mitochondria, the main source of free radicals. For this reason, it can be more effective than other antioxidants which are more evenly distributed throughout a cell. Q10 is also known as elixir of youth and it’s often used in cosmetic industry. However, due to protective property of human skin, Q10 used in creams can hardly penetrate deeper.
Why take CoQ10?
Because of its role in energy production and antioxidant activity it offers a range of health benefits. In fact CoQ10 is so important that our bodies form it naturally our whole life. The problem is that body synthesis of Q10 starts declining after the age of 20. The fall is especially significant in our hearts and other key organs (100% at the age of 20; 68% at the age of 40 and 43% at the age of 80). The most noticeable consequences of CoQ10 deficiency is loss of energy and chronic fatigue.
Ubiquinone and ubiquinol
CoQ10 is present in the human body in both, oxidized (ubiquinone) and reduced (ubiquinol) form. Ubiquinone is essential for CoQ10’s role in cellular energy metabolism, while Ubiquinol is essential for the antioxidant function of CoQ10.
Ubiquinol shifts to Ubiquinone during or following the absorption in the intestine, consequently its function is not affected by the form in which it is consumed. The key challenge is the initial CoQ10 absorption, which is highly improved in Q10Vital®.
Continuous conversion between Ubiquinone and Ubiquinol (reduction –oxidation) takes place in vivo. Depending on whether CoQ10 is in the blood and lymph or inside the mitochondria of the cells, it shifts to the form that is needed in the particular situation. In blood and lymph, CoQ10 primarily serves as an antioxidant. In the mitochondria, it supports the energy metabolism.
AGEING The accumulation of damage to the organism caused by free radicals represents an important part of the ageing process. As Q10 is present exactly where the majority of free radicals are generated it has a fundamental influence on the ageing process. Since the levels of Q10 in various tissues reduce with increasing age, supplementation can restore normal levels and slow down the ageing process.
CARDIOVASCULAR DISEASES are the leading cause of morbidity and mortality in the Western world. A decline in Q10 concentration in an ageing heart has been connected with various cardiovascular diseases. The beneficial effects of Q10 supplementation have been shown in many studies. Oral Q10 improves functional capacity, endothelial function and left ventricular systolic function in advanced chronic heart failure without any side effects. Q10 may also safely be offered as an adjuvant therapy to hypertensive and angina patients.
CHOLESTEROL AND STATINS Statins are drugs used to lower raised blood cholesterol levels, which have been associated with increased risk of heart disease. However, these drugs also influence the biosynthesis of Q10 and its plasma levels are lowered in the course of statin treatment. Statins competitively restrict the synthesis of mevalonate, a cholesterol precursor. Unfortunately, mevalonate is also the precursor of a dozen other end-products, including Q10. Compensating for such a Q10 decrease through the oral administration of Q10 is therefore often suggested.
NEURODEGENERATIVE DISEASES Patients with various neurodegenerative diseases have also been successfully treated. Substantial data have been accumulated about the beneficial effects of Q10 in neurodegenerative diseases in which there is impaired mitochondrial function and/or excessive oxidative damage, including Parkinson’s disease, Huntington’s disease and Friedreich’s ataxia. Clinical trials suggest that supplemental Q10 can slow down functional decline in these disorders.
MIGRAINE The efficiency of Q10 as a preventive treatment for migraine headaches was first investigated in 2002. The average number of days with a migraine was halved after 3 months of therapy with Q10. It was further reported that a Q10-deficiency may be common to migraine patients, while an efficacious and well tolerated treatment was also confirmed by a randomized control trial.
CANCER The supplementation of Q10 can sometimes improve the tolerability of cancer treatments. In individual cases, a partial or complete regression of cancer has also been observed in relation to Q10 supplementation.
OTHER CONDITIONS Beneficial effects of Q10 have also been reported in support of the immune system, the treatment of periodontal disease, male infertility and many other conditions
Global Coenzyme Q10 market was exhibiting strong, double-digit growth over the past 20 years. But the growth hasn’t stopped yet, with expected CAGR of above 9% till 2020.
One of the key drivers of growth is aging population around the world. United Nations report predicts that number of people in the world aged 60 years or over is projected to grow by 56 per cent, from 901 million to 1.4 billion, and by 2050, the global population of older persons is projected to more than double its size in 2015, reaching nearly 2.1 billion.
Aging population drives demand for anti-aging cosmetic, beauty supplements and functional drinks. CoQ10 is becoming a must have ingredient in these products, because of its antioxidant properties and effectiveness in eliminating free radicals.
Aging population together with new research is also fueling the demand for dietary supplements and medicines containing CoQ10. Its role in treating cognitive illness and cardiovascular ailments is well known, but new research show that CoQ10 could play an important role in medical treatment of cancer, neurological diseases, periodontal diseases and kidney failure.
Q10 antioxidant properties, positive effects on health and its role in energy metabolism make it a very popular dietary supplement for general population.
So, key areas of growth are cosmetics industry (anti-aging creams, sun cream lotions, etc.), medical applications (heart related diseases, cancer treatments, etc.), dietary supplements (energy, obesity, etc.) and new applications in food and beverage industry.